Makatussin Comp 80ml Syrup – Fast-Acting Relief for Dry, Irritating Coughs

Product Overview

Makatussin Comp 80ml Syrup is a pharmacy grade cough suppressant formulated for the short term treatment of dry, non productive cough in adults and adolescents over 12 years of age. This oral syrup combines an opioid cough reliever with an antihistamine to calm persistent, hacking coughs that keep you up at night and irritate your throat. It is commonly used during flu, colds, and upper respiratory tract infections when the cough is dry, painful, and not bringing up mucus.

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Active Ingredients & How It Works

Makatussin Comp 80ml Syrup contains a targeted combination of active substances that act on the cough center and respiratory tract:

• Dihydrocodeine hydrochloride (10 mg / 5 ml) – A codeine-like opioid cough suppressant that reduces the cough reflex in the brain, helping to break the cycle of constant, dry coughing.

• Diphenhydramine hydrochloride (15 mg / 5 ml) – A first‑generation antihistamine with additional cough-relieving and mild sedative effects, easing throat irritation and night-time cough.

Key excipients include sucrose, sorbitol solution 70%, sodium benzoate, citric acid, cherry flavour, and elderberry/fruit concentrate, giving the syrup a pleasant, cherry like taste for easier dosing even during intense cough episodes.

Together, these components help to:

• Suppress dry, unproductive coughs associated with colds and flu.

• Soothe irritated throat and airways, improving comfort and making breathing easier.

• Support better sleep at night by reducing nocturnal cough frequency.

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Indications – When to Use Makatussin Comp

Makatussin Comp 80ml Syrup is indicated for the symptomatic treatment of dry, irritating cough that is not accompanied by relevant mucus production, especially when the cough is:

• Related to flu like infections and common colds

• Causing sore throat, chest discomfort, or sleep disturbance

• Persistent and exhausting, with no significant phlegm

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Always consult a healthcare professional before using opioid-containing cough syrups, especially if you have chronic respiratory conditions or are taking other medicines.

Dosage & Administration (Adults and 12+)

For adults and adolescents over 12 years of age, typical dosing guidance from manufacturer and online pharmacy sources is:

• Recommended dose: 5 ml, 2–3 times daily

• Maximum duration without medical review: Usually 5–7 days if no improvement is seen

• A measuring cup is commonly supplied for accurate dosing (avoid household spoons).​

General usage tips:

• Take doses evenly spaced throughout the day (minimum 4‑hour interval).

• For night-time cough, the last dose is often taken shortly before bedtime to maximize sleep comfort.

• Do not exceed the prescribed dose; dihydrocodeine and diphenhydramine are both active CNS‑acting substances.

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Who Should Not Use Makatussin Comp 80ml Syrup?

Because Makatussin Comp contains opioid and antihistamine components, it is not suitable for everyone. Common contraindications and cautions listed by reputable sources include:

• Children under 12 years (many codeine/dihydrocodeine cough products are not recommended in this age group).

• People with severe respiratory depression, severe asthma, or chronic obstructive pulmonary disease, unless specifically advised by a doctor.

• Patients with known hypersensitivity to dihydrocodeine, codeine derivatives, diphenhydramine, or any excipients.

• Those with severe liver impairment, alcohol dependence, or a history of opioid misuse.

• Concomitant use with certain CNS depressants, sedatives, or alcohol increases the risk of drowsiness and respiratory depression.

Pregnant or breastfeeding individuals should only use Makatussin Comp if a physician decides the benefit clearly outweighs the risk, as opioid derivatives and sedating antihistamines can affect the infant.

Possible Side Effects

Like other codeine/dihydrocodeine cough syrups, Makatussin Comp 80ml may cause side effects, especially if doses are higher than recommended or combined with other sedating substances. Reported or expected adverse effects include:

• Drowsiness, dizziness, or sedation (do not drive or operate machinery if affected).

• Dry mouth, constipation, or nausea, typical for opioid-based products.​

• Mild confusion or blurred vision, particularly at higher doses or in sensitive individuals.

• Rarely, allergic reactions, respiratory depression, or paradoxical CNS stimulation.

If you notice difficulty breathing, severe drowsiness, confusion, chest tightness, or an allergic reaction, seek urgent medical attention and stop the medication.

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Storage & Handling

To keep Makatussin Comp 80ml Syrup safe and effective:

• Store at room temperature, usually between 15–25 °C, away from direct heat and sunlight.

• Keep the bottle tightly closed and out of the sight and reach of children.

• Do not use the syrup beyond the expiry date printed on the packaging.

• Dispose of unused medicine according to local pharmacy guidance; do not pour down the sink or toilet.

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